Peroxisome Proliferator-Activated Receptor-g Ligands Inhibit Choroidal Neovascularization

نویسندگان

  • Toshinori Murata
  • Shikun He
  • Masanori Hangai
  • Tatsuro Ishibashi
  • Xiao-Ping Xi
  • Sarah Kim
  • Willa A. Hsueh
  • Stephen J. Ryan
  • Ronald E. Law
  • David R. Hinton
چکیده

METHODS. PPAR-g expression in human retinal pigment epithelial (RPE) cells and bovine choroidal endothelial cells (CECs) was determined using an RNase protection assay and Western blot analysis. Two PPAR-g ligands, troglitazone (TRO) and rosiglitazone (RSG; 0.1–20 mM), were used to assess effects on RPE and CEC proliferation and migration and CEC tube formation in response to vascular endothelial growth factor (VEGF). The effects of intravitreal injection of TRO on laser photocoagulation–induced CNV lesions in rat eyes (15 experimental, 15 control, nine burns per eye) and cynomolgus monkey eyes (two experimental, two control, seven paramacular burns per eye) was assessed by fluorescein angiography and histologic evaluation.

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تاریخ انتشار 2000